MUTATION IN THE TWO-COMPONENT REGULATOR BAESR MEDIATES CEFIDEROCOL RESISTANCE AND ENHANCES VIRULENCE IN ACINETOBACTER BAUMANNII

Mutation in the two-component regulator BaeSR mediates cefiderocol resistance and enhances virulence in Acinetobacter baumannii

ABSTRACT Acinetobacter baumannii has become one of the most challenging pathogens in many countries with limited treatment options available.Cefiderocol, a novel siderophore-conjugated cephalosporin, shows potent in vitro activity against A.baumannii, including isolates resistant to carbapenems.To date, few reports on the mechanisms of cefiderocol

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Near Fixed Point Theorems in Hyperspaces

The hyperspace consists of all the subsets of a vector space.It is Connectors and Charge Leads well-known that the hyperspace is not a vector space because it lacks the concept of inverse element.This also says that we cannot consider its normed structure, and some kinds of fixed point theorems cannot be established in this space.In this paper, we

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Strategies used by emergency care professionals to handle interpersonal difficulties with patients: a qualitative study

Objectives Identify the strategies implemented by emergency care professionals when facing tension and interpersonal violence from patients and their friends and family.Design Descriptive 6 Piece Reclining Sectional qualitative study based on 38 semidirective interviews.Participants Doctors, nurses, nursing assistants and administrative staff.Setti

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Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division

Asymmetric division generates cellular diversity by producing daughter cells with 6 Piece Reclining Sectional different fates.In animals, the mitotic spindle aligns with Par complex polarized fate determinants, ensuring that fate determinant cortical domains are bisected by the cleavage furrow.Here, we investigate the mechanisms that couple spindle

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